Report №1: First Therapeutic Success in One Patient with Pleural Mesothelioma

Bless!

Today, I want to share some exceptional developments in one patient with terminal malignant pleural mesothelioma, whom we've been accompanying for multiple years now. Pleural mesothelioma ordinarily is an incredibly deadly disease. The median survival duration (i. e. when 50% of patients are still alive) is 8.7 months and the 3-year survival rate is in the neighbourhood of 10%.¹

Worse still, there are very few reports indicating anything approaching disease resolution in pleural mesothelioma. It may carry a better prognosis than does pancreatic cancer, but there isn't really any hope of tumour regression, never mind disease resolution.

I could find only 4 cases of spontaneous regression in malignant pleural mesothelioma, only two of which recorded survival without relapse.² The mechanism of such spontaneous relapse is believed to be immunological reaction to the tumour, complimentary and alternative therapies, or host response to the tumour.

Needless to say, that one doesn't typically recover from malignant pleural mesothelioma, nor that one does typically get to die of any other cause than the cancer. It's a quite the bleak outlook.

It's with great joy, thus, that I'm reporting first signs of regression in one patient with malignant pleural mesothelioma. The patient has multiple pericardial and peritoneal cancerous lesions. We've been running a quite aggressive immune-modulatory, anti-mitotic, and directly cytotoxic regimen with the patient, which has regrettably (but simultaneously invigoratingly) resulted in low-severity tumour lysis syndrome.

We've since been able to suppress tumour lysis syndrome, by modulating apoptotic pathways through oxidative stress, thereby enabling cancer cells to perish by apoptosis instead of necrosis. Secondary necrosis of apoptotic vesicles is still of issue and we're developing a immune-cycling regimen to ameliorate this, as I'm writing this.

Nonetheless, the largest lesion (pericardial) has had a marked regression in volume by about 30%, whilst the smaller lesions (peritoneal) have regressed less markedly in volume, making it somewhat harder to judge, whether they are genuinely regressive or just static.

Whilst treatment is yet ongoing and under constant improvement, these are incredible results, though they are still somewhat tenuous. Another CT imaging in 3 months' time should be able to confirm or deny genuine regression in all lesions. Until then, it's still somewhat incredible to me, that any regression was able to be detected in this normally never-regressive, ever-progressive form of aggressive cancer.

I thought I would share this with you as a point of hope and encouragement. No matter how dire your straits may seem, healing of cancer seems ever more possible for the common person with common means.

Toward swift healing and lasting health.

God bless,
Merlin L. Marquard.